23 Sep, 11:30
Manchester United remain unbeaten in the Premier League so far this season and sit joint-top in the Premier League with rivals Manchester City.
Jose Mourinho’s side have won four of their opening five games, only dropping points in the 2-2 draw with Stoke earlier this month.
While Southampton will be looking to make it three consecutive league wins after beating Watford and Crystal Palace.
The last time United took on Southampton at St Mary’s it ended goalless.
But with Romelu Lukaku and Marcus Rashford firing on all cylinders this season, goals will be expected.
However, a win for Southampton will allow them to get revenge for their EFL Cup final defeat last season.
Early team news
Defender Virgil van Dijk could make his first start in eight months against United, following a summer of endless speculation about his future.
The Holland international, who had been unavailable after suffering a serious foot injury in January and then handing in a transfer request, made his first-team return as a substitute against Crystal Palace last weekend.
Defender Matt Targett is a doubt with an ankle problem but Denmark midfielder Pierre-Emile Hojbjerg, who missed the game against Palace due to the birth of his daughter, is back in contention.
Marcos Rojo and Paul Pogba are United's major first-team absentees. The France midfielders is expected to be out for at least two months after tearing his hamstring against Basel in the Champions League.
Marcus Rashford and Anthony Martial have both excelled on the left flank of United's attack, and will be battling it out for a starting spot at Southampton.
Axel Tuanzebe is still nursing a back problem while Zlatan Ibrahimovic continues his rehabilitation from a knee ligament injury.
It’s a big game for?
Virgil van Dijk. After a summer of speculation linking the Dutchman with a move away from Southampton, it’s now back to reality for Virgil van Dijk. He made his return to competitive league football last weekend as a substitute but looks set to make his first start on Saturday since January. Having been absent with injury for such a long period, it’ll be interesting to see if Van Dijk is still the same defender who first caught the eye of Liverpool and Co this summer. He’ll be out to prove that this is very much the case.
Player to watch?
Marcus Rashford. The youngster was a delight to watch against Burton Albion in United’s midweek win over the Championship side. Intelligent, confident and purposeful, Rashford was the side’s standout player alongside Anthony Martial. Whether he starts or comes off the bench against Southampton, the forward will be the man to watch if his recent form is anything to go by.
Southampton 0 Manchester United 0, Premier League, May 2017
Manchester United 3 Southampton 2, League Cup, February 2017
Manchester United 2 Southampton 0, Premier League, August 2016
Southampton: W L D L W.
Manchester United: W W W D W.