Laurent Koscielny, Granit Xhaka and Pierre-Emerick Aubameyang all miss out and Shkodran Mustafi, Matteo Guendouzi and Alex Iwobi all start.
Jamaal Lascelles has been passed fit after recovering from a knee injury. He replaces Federico Fernandez for Newcastle.
Team to play Newcastle: Leno, Maitland-Niles, Sokratis, Mustafi, Monreal, Kolasinac, Guendouzi, Ramsey, Iwobi, Ozil, Lacazette.
Subs: Cech, Elneny, Mkhitaryan, Aubameyang, Suarez, Jenkinson, Nketiah.
Team to play Arsenal: Dubravka, Yedlin, Lejeune, Lascelles, Dummett, Ritchie, Hayden, Diame, Perez, Almiron, Rondon
Subs: Darlow, Ki, Shelvey, Muto, Kenedy, Fernandez, Manquillo.
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