Shaw has been missing from the team's starting lineup for the last three matches after accumulating 10 yellow cards in the current campaign.
The Englishman missed the 2-1 home win against West Ham on April 13 and Sunday's embarrassing 4-0 away loss to Everton.
However, there are doubts over the availability of Ander Herrera, Eric Bailly and Antonio Valencia, who have all been on the treatment table for long spells now.
Manchester welcomes their City neighbours on the back of a poor form, having won only twice in their last eight matches.
Their loss at the hands of Everton was a big blow to their top-four ambitions, and it could be worse if they drop points at Old Trafford.
Manchester City, on the other hand, will be in search of a crucial victory that will take them a step closer to defending their title, and a victory will take them above title challengers Liverpool.