Trabzonspor suffered a 1-0 loss to Getafe with Nigerian duo of John Obi Mikel and Anthony Nwakaeme sitting on the bench.
Jamie Mata scored the decisive goal for the visitors five minutes after the break after he was set up by Brazilian winger Kennedy.
The game presented Mikel with the chance to make his 10th Europa League appearance, but that was not to be on Thursday.
Having been able to secure just one point in five matches, Trabzonspor are sitting at the bottom of Group C and lost hope of advancing.
Getafe recorded the same 1-0 win over Trabzonspor on Matchday 1, with Angel scoring the winning goal.