Two Nigerian clubs Enugu Rangers and Enyimba lost their CAF Confederation Cup group stage opening matches to their North African rivals on Sunday.
Enugu Rangers suffered a 3-1 defeat at home against Egyptian opponents Pyramids, no thanks to the sending off of defender Temitope Olusesi.
It was coach Salisu Yusuf's first game in charge of Rangers after replacing Benedict Ugwu.
Two-time African champions Enyimba conceded twice within 19 minutes of the kick-off to lose 2-0 away to Moroccan outfit Hassania Agadir, who reached the quarter-finals last season.
Ibrahim Olawoyin put Rangers ahead on 29 minutes, but they battled after Olusesi was dismissed following a second yellow card just before half-time.
Mohamed Farouk equalised with a penalty nine minutes into the second half and Tunisian Amor Layouni and Islam Attia, from another spot-kick, scored in the closing stages for Pyramids.
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