Thiago Silva and Kai Havertz will travel to France and could feature when Chelsea play Rennes in their fourth Champions League clash on Tuesday night.
The duo missed the 2-0 win away to Newcastle in the Premier League on Saturday but will have a chance when Frank Lampard's men take to the pitch.
Havertz has not played since testing positive for COVID-19 on 4 November, while Silva was rested for the weekend match after his journey back from Brazil.
Speaking during his pre-match conference, Lampard gave an update on the team, including Christian Pulisic, who has struggled with injuries in recent weeks.
"Kai and Thiago both travel and they are fit for selection," he said.
Adding: "Christian stays back and doesn’t travel but the good news he has had good progression in the last week. The reason he is staying back is to get some physical work in to hopefully have him ready for selection for this weekend and onwards,"
Chelsea have a chance of qualifying from the group if they win tomorrow's match, but Lampard will not get carried away.
"We are in a decent position, but the minute we drop levels or don’t prepare right it will change. Rennes are a very accomplished team, we found that out at the Bridge, and I have a lot of respect for them,"
"People are saying if we get the right result the group will be done in terms of qualification, but if we get the wrong result we make it a difficult couple of games in the group because we go to Seville next. We have to respect this game, and we have to keep focusing on ourselves to keep that form going,"
The Blues lead their group on seven points, same as Spanish side Sevilla, but have a superior goal difference.