The Manchester derby is back and this time, a Carabao Cup final ticket will be up for grabs.
The red half of Manchester will play host to the Blue side, hoping to revenge last season's defeat in the same stage.
Their quest will be boosted with the news that a number of first-team players will miss the clash after testing positive for COVID-19.
Coach Ole Gunnar Solskajer will have decisions to make but will have a fresher team compared to City, who were in action on Sunday night.
With Victor Lindelof a doubt because of his back injury, the impressive Eric Bailly could start in defense alongside Harry Maguire.
Aaron Wan-Bissaka will be expected to take his spot at right-back, with the left-back a battle between Alex Telles and Luke Shaw.
Having started in December's league game against City, Shaw could be preferred once again at Old Trafford on Wednesday night.
The midfield also presents Solskjaer with a selection headache with Paul Pogba, Nemanja Matic, Fred, and Scott McTominay all available.
Upfront though Edinson Cavani will miss the clash as he starts his three-match ban following a racially sensitive post on social media.
Marcus Rashford and Anthony Martial are available, and so is Mason Greenwood.
Manchester City, on the other hand, could miss a number of their key players as they are still self-isolating following positive COVID-19 tests.
Kyle Walker, Gabriel Jesus, Ederson, Eric Garcia and Ferran Torres all missed the match at Stamford Bridge, and could still sit out Wednesday night's match.
Aymeric Laporte is also a doubt after picking a minor hamstring injury.