Man City moved five points clear at the top of the Premier League table with a stunning 4-1 win against Liverpool at Anfield on Sunday evening.
Ilkay Gundogan scored a double, with Raheem Sterling and Phil Fodden sealing the victory, while Liverpool's consolation was scored from the spot by Mohamed Salah.
Jurgen Klopp was able to call on Alisson Becker, Sadio Mane, and Fabinho, who missed the 1-0 loss to Brighton last time out, replacing Caoimhin Kelleher, Nathaniel Phillips, and Xherdan Shaqiri.
Pep Guardiola on the other hand made two changes, bringing in Oleksandr Zinchenko and Phil Foden for Aymeric Laporte and Gabriel Jesus.
City started the brighter of the two, with Liverpool happy to sit back and stalk their possession.
Thiago Alcantara got into the referee book after just four minutes, his third of the season, following a challenge on Ilkay Gundogan.
The two sides though had to wait until the 25th minute for any clear chance on goal, with Alexander-Arnold neatly tricking Zinchenko on the outside before delivering a beautiful cross into the box only for Mane to plant his header inches over the crossbar.
Man City finally had a chance to grab the opener when they were awarded a penalty after Fabinho brought down Sterling inside the box.
The midfielder however sent his kick miles over the bar as Liverpool breathed a sigh of relief as the game went into the break with both sides tied at 0-0.
The game exploded into life in the second half as City scored thrice with the hosts having their consolation from the penalty spot.
Guardiola's side took a deserved lead in the 50th minute when the lively Sterling cut off the left and dribbled past Alexander-before finding Foden who drilled a low effort from 12 yards that Alisson flicked away with one-hand but only as far as Gundogan, who poked home for the opener.
Liverpool went all out in search of the equaliser, and after a number of attempts, it arrived in the 62nd minute after Mohammed Salah was brought down by Ruben Dias inside the box, resulting in a penalty.
The Egyptian easily beat Ederson in goal with a perfect penalty to restore parity.
City then thought they had regained their lead in the 72nd minute when John Stones tapped in from a free-kick, but his goal was ruled out for offside.
It was 2-1 though a minute later as Alisson committed two rare mistakes in a moment of madness, with the second a straight pass to Bernando Silva about 30 yards out.
Silva found Foden, who easily beat Henderson before pulling it back for Gundogan to score his second of the night.
It was game over in the 77th minute as Sterling scored from close range following yet another Alisson mistake, who once again played a pass straight to Silva on the edge of the box.
Foden then produced a moment of brilliance to make the scores 4-1 with an 83rd-minute strike, that almost went through Alisson in goal.
The win, which was City's first at Anfield in 17 years saw Guardiola's side open a 10-point gap over Liverpool, and are confidently perched at the top, five points ahead of Man United in second.
For Jurgen Klopp, it was a disappointing night as they have now lost home games in a row, possibly ending their title defense.