In a 3-0 victory over fellow south-coast club Bournemouth on Saturday, Southampton became the first team through to the FA Cup semifinals, with Nathan Redmond scoring twice and setting up another goal.
In the 37th minute, Redmond slipped in Moussa Djenepo for the opener, then scored a superb solo goal in first-half stoppage time, dribbling into the area and skirting a challenge before firing a shot into the top corner.
After Stuart Armstrong's attempt from outside the area came back off the post, Redmond added the third with an accurate, angled shot into the bottom corner in the 59th minute.
Southampton also advanced to the semifinals in 2018, but were defeated by Chelsea.
Manchester City take on Everton in the other last-eight match of the day.
The other quarterfinal games are on Sunday and both are all-Premier League matchups: Leicester vs. Manchester United and Chelsea vs. Sheffield United.