Tottenham Hotspur will play their first match since the departure of Jose Mourinho, with Ryan Mason set to take charge of the team for the remainder of the season.
Mason will become the Premier League's youngest-ever head coach at the age of 29 years and 312 days.
The former midfielder beats Attilio Lombardo's record, who was 32 years and 67 days old when he took charge of Crystal Palace's match against Aston Villa in March 1998.
Spurs will however miss the services of Harry Kane after he picked an injury in their last match against Everton.
The League's top scorer is also a doubt for Sunday's EFL Cup final match against Pep Guardiola's Manchester City.
Southampton have no fresh injuries and will be expected to be at full strength.
- Spurs have won eight of their last nine Premier League home matches against Southampton
- The only exception was a 2-1 loss at White Hart Lane in May 2016
- Southampton have scored in each of their last 10 PL meetings with Spurs
- However, Saints have only kept one clean sheet themselves in that run and have only won three of the contests (D1 L6)
- Saints have drawn their last three PL away matches against London sides
- Only once before have they drawn four consecutive trips to the capital in the top flight, doing so from 1979 to 1980.