Premier League side Arsenal travel to Estadio de la Ceramica to face Villarreal in the first leg of the Europa League semi-final.
It will be the first match when Arteta, leading Arsenal will face the former Gunners coach Unai Emery who joined Villarreal after his axing.
Arteta has made a single change to the team that lost 1-0 to Everton on Friday. Martin Odegaard is back in the XI, with Eddie Nketiah dropping to the bench.
Nicolas Pepe will lead the line for Arsenal, with captain Pierre-Emerick Aubameyang fit to take a place on the bench after recovering from malaria. David Luiz also passes his fitness test, but Alexandre Lacazette and Kieran Tierney do not make the matchday squad.
Villarreal XI: Rulli, Foyth, Albiol, Pau, Pedraza, Parejo, Capoue, Trigueros, Chukwueze, Alcacer, G Moreno.
Subs: Asenjo, Gaspar, Mori, Bacca, Estupinan, A Moreno, Coquelin, Costa, Gomez, Yeremy, Alex, Nino.
Arsenal XI: Leno; Chambers, Holding, Mari, Xhaka; Partey, Ceballos; Saka, Ødegaard, Smith Rowe; Pepe.
Subs: Ryan, Bellerín, Gabriel, David Luiz, Cedric, Elneny, Nelson, Willian, Martinelli, Nketiah, Aubameyang, Okonkwo.