Gareth Bale is expected to miss eight weeks due to a hamstring injury.
Bale tore a muscle in his right hamstring during a training session on Saturday, missing games against Celta Vigo and Inter Milan as a result.
Bale is expected to be out for a long time, according to AS, which might be terrible news for Wales and caretaker manager Robert Page.
The 32-year-old is expected to miss a number of critical Real Madrid matches, including the El Clasico against Barcelona on October 24.
Wales, on the other hand, are now third in their World Cup qualification group. Bale is expected to miss the away matches against the Czech Republic and Estonia next month. In addition, he will have to race against the clock to be fit for the November games against Belarus and Belgium at home.
Bale's stint at Real has been marred by ailments, with the Welshman suffering 24 separate issues since joining the club in 2013.
Bale was loaned back to Tottenham Hotspur last season, where he scored 16 goals in 34 games, and he has made three appearances in LaLiga since his return to Real, scoring once in a 3-3 tie with Levante.
Bale's current Real Madrid deal expires next summer, and his future is uncertain.