After a thrilling week in Europe, attention now shifts to the domestic league this weekend, with a number of exciting clashes lined up.
It's still tight in the English Premier League, LaLiga, and Serie A, with every match as important as any other.
We take a look at some clashes that you should not miss this weekend.
Man City vs West Ham (Saturday)
The English Premier League leaders have swept anything that has come before them in the last few weeks, opening a 10-point gap at the top of the table. They have won 13 successive games but will face a tricky side in West Ham, who surprisingly sit fourth.
David Moyes' side have grown match in, match out, and have kept alive their hopes of playing in Europe next season.
Can they stop Pep Guardiola's engines?
Sevilla vs Barcelona
LaLiga's fixture of the weekend will be at the Estadio Ramon on Saturday afternoon as Sevilla welcome Barcelona in what promises to be a classic contest.
Only two points separate the two on the table, with Barcelona sitting third on 50 points, while Sevilla are fourth on 48.
Julen Lopetegui's side have a match at hand and could move above Barcelona with a win. Barcelona have been wobbly this season, and this definitely promises to be an exciting affair for the neutrals.
Leicester vs Arsenal
Third-placed Leicester welcome Arsenal in a big game at the King Power Stadium on Sunday, hoping to erase their disappointment of being knocked out of the Europa Cup on Thursday night.
The Gunners, on the other hand, arrive at King Power on high spirits, having made it through thanks to a 3-2 win over Benfica.
Arsenal will be looking to end a run of two successive Premier League away defeats, losing to Wolves and Aston Villa respectively.
The hosts, on the other hand, will be keen on keeping pace with Man City and boost their hopes of playing in the Champions League.
Chelsea vs Man United
A real cracker is expected at Stamford Bridge as Ole's Man United visits Tuchel's Chelsea. The Blues seem to have rediscovered their form and are unbeaten in their last eight games.
United, on the other hand, remains the only team across Europe's top leagues yet to lose away from home, with their last defeat on the road coming in January 2020.
Ole's side will fight to secure a fourth successive win at the Bridge in all competitions for the first time having won there thrice already.
⛔️ ⛔️ ⛔️— Chelsea FC (@ChelseaFC) February 25, 2021
Sensational stuff from Edouard Mendy when we last faced Man Utd! 👏 pic.twitter.com/hCaEykxj38
Villreal vs Atletico Madrid
Diego Simeone's side have faltered in recent weeks and will see the trip to Villareal as the perfect chance to reboot and get their campaign firmly on track.
Villarreal, though are no pushovers, losing just once at home (5-6-1) this season, and will be a tough opponent for Simeone.
Roma vs AC Milan
With the two sides impressive this season, expect fireworks at the Stadio Olimpico. Milan were outclassed in their last match as they went down 3-0 against Inter Milan, their second in a row.
Their hosts settled for a 0-0 draw way to Benevento despite the hosts playing with 10 men for the larger part of the match.
Five points separate the two sides, who are not far off the top, where Inter seat comfortably.