Injury-hit Dortmund comes into this encounter on the back of a dismal 4-2 away defeat to Bayern Munich in the Bundesliga.
Undefeated in their last six competitive matches at Signal Iduna Park (W3, D3), Dortmund will be looking to secure a place in the Champions League quarter-finals for the first time since 2016/17.
Victories against Krasnodars and Rennes on Matchday 4 and 6 put Sevilla in a position to claim three consecutive away UEFA triumphs for the first time since 2006/07, qualifiers excluded.
Borussia Dortmund XI: Hitz, Schulz, Hummels, Can, Morey, Delaney, Dahoud, Bellingham, Hazard, Reus, Haaland
Sevilla XI: Bono, Jesús Navas, Kounde, Diego Carlos, Acuna, Jordan, Fernando, Oscar, Ocampos, Suso, En-Nesyri