The Spanish La Liga is set to start on Friday night, with defending champions Barcelona playing away to Athletic Bilbao without keyman Lionel Messi.
The League starts as the English Premier League enters week two, with matches from Saturday all the way through Monday.
With most leagues slowly returning for the new season, we look at key matches that you should not miss this weekend.
1. Manchester City vs Tottenham Hotspur
The Premier League defending champions will be hosting the Lilywhites at the Etihad Stadium on Saturday keen on getting one against one of the top-six sides early in the campaign. City were at their clinical best in the opening weekend, hammering West Ham 5-0 away to take lead in the standings after week one.
Spurs on another hand struggled to beat new boys Aston Villa 3-1, with Christian Eriksen getting off the bench to spark a comeback. It will be the third time this year that the two sides clash at the stadium, having met in the League and the Champions League as well.
2. Chelsea vs Leicester City
Chelsea are eager to get their first win of the season, after a thorough 4-0 beating at Old Trafford against Manchester United on Sunday. The Blues managed to recover well and put in an assured performance against Liverpool in midweek during the Super Cup final in Istanbul and will be keen on registering their first win under manager Frank Lampard. Leicester beat the Blues 1-0 last time they visited the Bridge, and Chelsea will be eager to avenge the loss.
3. Athletic Bilbao vs Barcelona
You can't miss the opening match of the new La Liga season. And it promises to be a cracker of a match, considering Barcelona were not able to beat the side last season, having settled for a 1-1 and 0-0 draw. The defending champions will be keen on starting the season on a high, and will be forced to do so without their key man, Lionel Messi.
4. Celta Vigo vs Real Madrid
Zinedine Zidane's Madrid has been one of the busiest sides in the summer transfer with seven new faces including Eden Hazard. Despite doing a double over Vigo last season, the side offered stern opposition in both matches, and ended the season with a run of five games unbeaten at home, winning four of those against the likes of Villarreal, Real Sociedad, Girona, and Barcelona. It will also be a good time to watch the new-look Los Blancos.
5. Wolves vs Manchester United
Wolves was a thorn in many of the top six's flesh last season. They beat United twice at the Molineux Stadium and will be eager to repeat the same. United, on the other hand, started the season in emphatic fashion, beating rivals Chelsea 4-0 at home on Sunday. Will they keep the momentum against a dodgy Wolves side, don't miss the action on Monday night.