Eddie Nketiah makes his full Premier League debut for Arsenal, while Dani Ceballos plays in the league for the first time since the start of November.
The wing-backs Danny Rose and Valentino Lazaro make their first starts since moving to Newcastle on loan.
Livescore: Arsenal vs Newcastle
Arsenal XI Leno; Bellerin, Mustafi, David Luiz, Saka; Ceballos, Xhaka; Pepe, Ozil, Aubameyang; Nketiah.
Substitutes: Martinez, Sokratis, Kolasinac, Torreira, Willock, Martinelli, Lacazette.
Newcastle XI: Dubravka; Fernandez, Lascelles, Clark; Lazaro, Bentaleb, S Longstaff, Rose; Almiron, Saint-Maximin; Joelinton.
Substitutes: Darlow, Schar, Lejeune, M Longstaff, Ritchie, Hayden, Atsu.
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