Manchester United will welcome Istanbul Basaksehir at Old Trafford in the return leg of the Champions League Group stage tie.
United suffered a 2-1 loss in the first leg and may need six points from their remaining Champions League group stage games to advance to the next phase.
Edinson Cavani makes his first Manchester United start while Donny van de Beek comes into the side with Nemanja Matic and Juan Mata dropping to the bench from the side that beat West Brom 1-0 at Old Trafford on Saturday.
Man United XI: De Gea, Wan-Bissaka, Telles, Maguire, Lindelof, Fred, Van de Beek, Fernandes, Martial, Rashford, Cavani.
Subs: Grant, Henderson, Fosu-Mensah, Mengi, Tuanzebe, Williams, Mata, Matic, Pellistri, Greenwood, Ighalo.
Istanbul XI: Gunok, Rafael, Skrtel, Epureanu, Mbombo, Ozcan, Kahveci, Chadli, Turuc, Visca, Ba.
Follow Man United vs Istanbul Basaksehir live on Futaa.