CAF Confederations Cup holders Raja Casablanca of Morocco and Egyptian giants Zamalek SC were both held as the competition entered its second matches in the group stage.
There were a lot of games played in round two with RS Berkane, Nkana, Asante Kotoko and Petro Atletico all winning their games.
Berkane went top of Group A as they came from behind to beat visiting fellow Moroccans Hassania Agadir 2-1. Holders Raja Casablanca, the third team from Morocco in the group, were surprisingly held to a 0-0 draw in Rabat by Congo Brazzaville visitors AS Otoho Oyo.
Nigeria's Enugu Rangers preserved their unbeaten record with a 1-1 with CS Sfaxien in Tunisia on Wednesday. The other match in the group also ended in stalemate as Salitas drew 0-0 with Tunisia's Etoile du Sahel in Burkina Faso.
Zambian club Nkana maintained a record of never losing a continental club match at home by fighting back to edge Sudanese visitors Al Hilal 2-1.
Nkana stretched their unbeaten run in all African competitions to 57 matches, winning 41 and drawing 16 at various Zambian venues.
Former African champions Asante Kotoko of Ghana defeated the other Zambian challengers, Zesco United, 2-1 in Kumasi.
Algerian visitors NA Hussein Dey snatched a dramatic 1-1 draw against hosts Zamalek in the Egyptian city of Alexandria.
Angola's Petro Atletico dominated Kenya's Gor Mahia more in Luanda than their 2-1 win suggests. Manguxi and Brazilian Tony scored in the first-half with Nicholas Kipkirui grabbing a consolation for the Kenyans in stoppage time at the end of the game.
Group winners and runners-up advance to the quarter-finals of Africa's second-tier club competition.