The English Premier League will return this weekend after a two-week break occasioned by the international break.
Many managers will however have to deal with injuries to their key players, which is often the case after such breaks.
Some are however fortunate to have their teams back unscathed ahead of a busy two-month period.
So, which clubs among England's top six are most affected by the injuries?
🔴 Manchester United
Raphael Varane being withdrawn during France's UEFA Nations League final match against Spain was an unwelcome sight for Man United fans and coach Ole Gunnar Solskjaer.
United have won just twice from their last six games, and pressure is piling on the Norwegian manager.
They head to Leicester hoping to get their season back on track but will have to do without a number of players.
Varane joins captain Harry Maguire on the sidelines, while Fred and Edinson Cavani will be unavailable as they played in a World Cup qualifier match on Friday morning, meaning they won't make it back to England in time for the match.
The Gunners seemed to have turned a corner just before the break with three wins and a draw from their last four games.
Coach Mikel Arteta has benefited from having his key players in the last number of games and will be pleased to learn that there are no fresh injuries during the break.
🔵 Manchester City
City, just like other Premier League teams will miss the South American players who featured in the late World Cup qualifier matches.
Ederson and Gabriel Jesus are definitely out of City's clash against Burnely, same as Ferran Torres, who picked an injury while playing for Spain in the UEFEA Nations League.
The forward is expected to be out for a few weeks.
Thomas Tuchel will be hoping to have record-signing Romelu Lukaku back after he suffered a minor injury while featuring for Belgium in the UEFA Nations League.
He was released from camp as the Red Devils prepared for the third-place play-off match against Italy, with coach Roberto Martinez describing the injury as a 'minor overload'.
One boost for Tuchel though is the return of N'Golo Kante, who was self-isolating after a positive COVID-19 test just before the break.
Diogo Jota is perhaps the only worry as Jurgen Klopp prepares for Saturday's early kick-off at Watford because of a muscle injury while on international duty,
Klopp will however be without the influential pair of Alisson Becker and Fabinho, who were all involved in Friday morning's World Cup qualifier match against Uruguay.
The pair is expected to head straight to Spain for their Champions League match against Atletico Madrid next week.
Emerson Royal, Giovani Lo Celso, Cristian Romero, and Davinson Sanchez will all be missing from Nuno Espirito's side when they face Newcastle on Sunday.
The quartet traveled to feature in the South America World Cup qualifier matches.