England manager Gareth Southgate has named the side's youngest starting line-up since 1959 with an average age of 23 years and 255 days.
Pickford starts in goal with Alexander-Arnold, Chilwell, Stones, and Maguire lining up in defense as England play their 1,00th international match.
Harry Winks takes his place in Central midfield, and Alex Oxlade-Chamberlain stands alongside him.
Jadon Sancho takes Raheem Sterling's role on the wing, with Manchester United forward Marcus Rashford operating on the other wing.
Chelsea attacking midfielder Mason Mount will operate behind Harry Kane, who will be tasked with leading the lines for the Three Lions.
The likes of Tammy Abraham, Callum Hudson-Odoi, Declan Rice and James Madison are all on the bench.