Real Madrid manager Zinedine Zidane has ruled out the duo of Gareth Bale and James Rodriguez from the LaLiga fixture against Eibar on Saturday.
It means Bale and Rodriguez will now return after the international break where both players have been called up by their countries despite the muscle problems.
The pair have started individual fitness programmes but will not be considered for selection until they can complete full training sessions alongside the rest of the first team.
"They haven't been fit enough to play," Zidane said at Friday's pre-match news conference.
"If they're going to go [away on international duty], they're going to go. They've got five or six days to see if they're fit enough to play for their country. They're not fit enough to play on Saturday.
"They haven't trained with the team. They've been training a little but not at the same pace as their team-mates. If players aren't training with their team-mates they can't play.
"They're not injured right now."
Wales winger Bale, 30, has not played a single minute since a Euro 2020 qualifier close to a month ago, while 28-year-old midfielder James has missed Madrid's past three matches.