Left-back Brandon Williams has been handed his first start in the league for Manchester United when they host Brighton and Hove Albion on Old Trafford on Sunday.
The player who has been a consistent figure for United in the Europa League comes in for Ashley Young who doesn't make the matchday squad with Harry Maguire handed the captain's armband in the test.
The trio of Marcus Rashford, Anthony Martial and Daniel James lead the attack as the home side look to bounce back from their last week's loss to Bournemouth.
Manchester United Starting XI: De Gea; Wan-Bissaka, Maguire, Lindelof, Williams; McTominay, Fred; James, Rashford, Andres; Martial
Subs: Romero, Jones, Rojo, Mata, Lingard, Garner, Greenwood