Redbull Salzburg head coach Jesse Marsch has maintained the team that started in midweek against KRC Genk in a UEFA Champions League match at Luminus Arena.
Daka who was named as the Club's November player of the month will partner the Korea Republic forward Hee-Chan Hwang in attack as Norwegian teenage Sensation Erling Braut Haaland only makes the bench again.
Mwepu, on the other hand, will line up alongside Zlatko Junuzovic, Takumi Minamino and Dominik Szoboszlai in midfield.
Salzburg is hoping to start December on a high note and maintain their lead at the summit of the Austrian Bundesliga.
Kick-off for the match is set at 15:00hrs.