Champions League defending champions Liverpool will take their title defense campaign to the Spanish capital to face Atletico Madrid in the Round of 16 following Monday's draw.
English sides have been drawn against continental giants, with Manchester City, too traveling to Spain to face Real Madrid in one of the other pairings.
Chelsea will face familiar foes in Bayern Munich, with Jose Mourinho's Tottenham paired against RB Leipzig.
Barcelona will face Napoli, while Italian champions Juventus will be up against Lyon.
The round of 16 matches will be played in February and March, with the quarter and semifinals set for April.
Champions League knockout stage - the key dates
- February 18/19 & 25/26: Round of 16 - first leg
- March 10/11 & 17/18: Round of 16 - second leg
- April 7/8: Quarter-finals - first leg
- April 14/15: Quarter-finals - second leg
- April 28/29: Semi-finals - first leg
- May 5/6: Semi-finals - second leg
UCL Last 16 Full Draw
- Borussia Dortmund v Paris Saint Germain
- Real Madrid v Manchester City
- Atalanta v Valencia
- Atletico Madrid v Liverpool
- Chelsea v Bayern Munich
- Lyon v Juventus
- Tottenham Hotspurs v RB Leipzig
- Napoli v FC Barcelona
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