The significant news coming out of the Arsenal camp is that Alexandre Lacazette is not included in the team.
The striker did not train this week, and manager Mikel Arteta stated that he did so for "private reasons." Eddie Nketiah takes his spot up forward, while Nuno Tavares starts at left-back.
Here are full team news:
Southampton team news
Starting XI: Forster, Valery, Bednarek, Lyanco, Walker-Peters, Romeu, Ward-Prowse, Perraud, S.Armstrong, Elyounoussi, Broja.
Subs: Caballero, Stephens, Livramento, Salisu, Redmond, Tella, A.Armstrong, Adams, Long.
Arsenal team news
Starting XI: Ramsdale, White, Gabriel, Saka, Odegaard, Cedric, Tavares, Sambi Lokonga, Nketiah, Xhaka, Martinelli.
Subs: Leno, Smith Rowe, Holding, Pepe, Elneny, Azeez, Ogungbo, Swanson, Hutchinson.