Manchester United will host AS Roma at Old Trafford tonight in the first leg of the Europa League semi-final.
United boss Ole Gunnar Solskjaer has made three changes to the side that settled for a goalless draw on Sunday.
David de Gea replaces Dean Henderson in goal, while Daniel James and Mason Greenwood make way for Paul Pogba and Edinson Cavani.
Smalling and Henrikh Mkhitaryan start against their former club, while former Manchester City striker Edin Dzeko leads the Roma attack.
Man United XI: De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, McTominay, Fred, Rashford, Fernandes, Pogba, Cavani.
Subs: Grant, Henderson, Bailly, Mata, Greenwood, Diallo, James, Telles, Matic, Williams, Van de Beek, Tuanzebe.
Roma XI: Pau Lopez, Smalling, Cristante, Ibanez, Karsdorp, Diawara, Veretout, Spinazzola, Pellegrini, Mkhitaryan, Dzeko.
Subs: Mirante, Fuzato, Villar, Santon, Mayoral, Kumbulla, Perez, Bruno Peres, Ciervo, Darboe.