Chelsea will be looking to avenge the 2-0 defeat to Kotoko when they host them at the Berekum Sports Stadium.
Kotoko lead Group A with 13 points after the first round of matches, while Group B is led by Karela United.
After a chaotic first leg that saw Aduana Stars players and fans injured, the two teams will once again meet at the Tarkwa and Aboso Park on Sunday,
Here are the matches.
Medeama vs Aduana Stars
Berekum Chelsea vs Asante Kotoko
Bechem United vs Eleven Wonders
Elmina Sharks vs Dreams
WAFA vs Dreams
Inter Allies vs Hearts
Liberty vs Karela