English Premier League champions Manchester City will host high-flying Chelsea on Saturday, in what will be the key match of the weekend.
City, who have struggled this season, lost their last match away to league leaders Liverpool and will be eager to get back to winning ways.
Pep Guardiola's men will have to do the job without some of their key men, who are out either injured or suspended.
Silva was handed a one-match suspension following charges by the FA in relation to a tweet he posted on his twitter account comparing teammate Benjamin Mendy to a character on a packet of Conguitos.
According to a statement on the body's website, the Portuguese has also been fined £50,000 in addition to the suspension.
"Bernardo Silva has been suspended for one first-team competitive fixture, fined £50,000 and must complete face-to-face education after admitting a breach of FA Rule E3,
Other absentees include Leroy Sane, who suffered an injury at the start of the season in a Community Shield tie against Liverpool and is set to return next year.
According to Pep Guardiola, he expects the German back from February.
"He's coming back before the end of the season. In January, December, February could be perfect. He should be perfect."
The Frenchman suffered a serious injury against Brighton in the Premier League and underwent successful surgery.
The match against Chelsea will come too soon for him, as he continues his rehabilitation.
Zinchenko is out for four to six weeks, having suffered a knee injury.
"He had a contact with a knee, something in the bone. Four weeks, five weeks, more or less," revealed Guardiola when highlighting his injury concerns.
"It was something to clean a little bit. Not a big issue. Five weeks, six weeks.."