Spurs will be without suspended Eric Dier and injured Dele Alli. The England midfielder is suffering from a hamstring injury and will miss out while defenders Japhet Tanganga and Juan Foyth are also injured.
The Gunners will be without striker Eddie Nketiah after the England Under-21 international was sent off in Tuesday’s 1-1 draw with Leicester.
He will miss the next three games after an appeal against the decision was unsuccessful.
Pablo Mari, Bernd Leno, Gabriel Martinelli and Calum Chambers are definite absentees.
Teams in full
Tottenham XI: Lloris, Aurier, Alderweireld, Sanchez, Davies, Sissoko, Winks, Lo Celso, Son, Kane, Moura
Subs: Gazzaniga, Vertonghen, Lamela, Sessegnon, Bergwijn, Ndombele, Skipp, Fernandes, Tanganga
Arsenal XI: Martinez, Mustafi, Luiz, Kolasinac, Bellerin, Ceballos, Xhaka, Tierney, Pepe, Lacazette, Aubameyang
Subs: Macey, Sokratis, Torreira, Maitland-Niles, Holding, Soares, Nelson, Willock, Saka.
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