Everton striker Dominic Calvert-Lewin has been rewarded for his fine start to the season by being handed his first call up to the England national team.
Lewin is the current Premier League Top Goalscorer with five goals (the same as Jamie Vardy of Leicester) this coming after hitting a career-best 15 goals in the past season.
19-year-old Saka has featured just three times for Arsenal during this campaign but broke into the first-team and impressed while playing at full-back for the Gunners last season.
Another debutant in the team is Leicester City’s Harvey Barnes who has helped his team to the top of the early Premier League table, with the 22-year-old scoring in the Foxes' win over Burnley.
Manager Gareth Southgate has left out Greenwood and Foden after the pair were sent home from Iceland last month for breaching coronavirus protocols; there is a place for Manchester United defender Harry Maguire who was dropped from the last squad.
Southgate has recalled fit-again Ben Chilwell, Harry Winks and Marcus Rashford returning to the fold with Liverpool captain Jordan Henderson making the cut despite picking up an injury issue in the Reds' win over Chelsea.
Dean Henderson (Manchester United), Nick Pope (Burnley), Jordan Pickford (Everton).
Trent Alexander-Arnold (Liverpool), Ben Chilwell (Chelsea), Conor Coady (Wolves), Eric Dier (Tottenham), Joe Gomez (Liverpool), Michael Keane (Everton), Harry Maguire (Manchester United), Ainsley Maitland-Niles (Arsenal), Tyrone Mings (Aston Villa), Bukayo Saka (Arsenal), Kieran Trippier (Atletico Madrid), Kyle Walker (Manchester City).
Jordan Henderson (Liverpool), Mason Mount (Chelsea), Kalvin Phillips (Leeds United), Declan Rice (West Ham), James Ward-Prowse (Southampton), Harry Winks (Tottenham).
Tammy Abraham (Chelsea), Harvey Barnes (Leicester), Dominic Calvert-Lewin (Everton), Jack Grealish (Aston Villa), Danny Ings (Southampton), Harry Kane (Tottenham), Marcus Rashford (Manchester United), Jadon Sancho (Borussia Dortmund), Raheem Sterling (Manchester City).