Everton suffered a 1-3 defeat at Goodison Park after Manchester United came from 1-0 down, thanks to goals from Bruno Fernandes and Edinson Cavani.
The Toffees took the lead through Bernard's goal but it wasn't enough to sustain the hosts as United bounced back to get their much-anticipated three points.
Edinson Cavani scored the third goal after coming off the bench and it sealed the deal for the visitors.
United boss Ole Gunnar Solskjaer to BT Sport: "We were set up to fail. The kick-off time set us up to fail. We have been to Turkey, played loads of games this season already, we got back Thursday morning and we are playing Saturday lunchtime, it's an absolute shambles.
"These boys deserve better. Luke Shaw has got injured because of it. It's a hamstring which might be a long one and Marcus Rashford might be struggling.
"The authorities set us up for fail, who is responsible? We've had enough of that. Players this season, in these times, a pandemic, mentally and physically it's draining. Let us play on a Sunday, there's an international break after this, it's a joke.
"The players were brilliant. Cavani is getting better and better."