Former Liverpool winger Xherdan Shaqiri set up his first goal for Lyon when he assisted on central defender Jason Denayer’s 64th-minute header.
It was the club's second win of the season under new coach Peter Bosz; an outing that saw them move up to seventh in the French league after beating Strasbourg 3-1 on Sunday.
New signing Jerome Boateng, who joined from Bayern Munich late in the summer transfer window, came on a few minutes before Denayer’s goal.
Moussa Dembele had put Lyon ahead after just seven minutes when he chested down a long pass from Bruno Guimares and rifled home with his left foot.
Houssem Aouar picked out fellow midfielder Lucas Paqueta for the third goal in the 86th to cap a comfortable night ahead of a difficult trip next Sunday to face PSG. Striker Habibou Diallo grabbed a consolation goal with a penalty deep into stoppage time.
LOVE everything about this video.— LFC Transfer Room (@LFCTransferRoom) September 13, 2021
Lyon fans showing Shaqiri love and support chanting his name, Shaq a knowledges them with a thumbs up and later with a superb cross that helps score the goal! 🎯💪🏻#YNWA Power Cube @XS_11official pic.twitter.com/Sg28vQm503