Antonio Conte has made two changes to the team which came from behind to beat Leeds in Tottenham’s last Premier League outing almost a fortnight ago.
Davinson Sanchez and Oliver Skipp return to the Spurs starting line-up in place of Japhet Tanganga and Harry Winks, who both drop to the bench.
Spurs XI: Lloris, Sanchez, Dier, Davies, Royal, Hojbjerg, Skipp, Reguilon, Moura, Son, Kane.
Subs: Gollini, Doherty, Winks, Gil, Sessegnon, Alli, Bergwijn, Tanganga, Ndombele
Brentford XI: Fernandez, Goode, Jansson, Pinnock, Canos, Janelt, Onyeka, Norgaard, Henry, Mbeumo, Toney.
Subs: Cox, Jensen, Forss, Wissa, Ghoddos, Baptiste, Roerslev, Maghoma, Stevens.